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<B>Sleep characteristics, CVD, and cognitive risks
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   Lead Investigator:    Soomi Lee
   Institution      :    University of South Florida
   E-Mail           :    soomilee@usf.edu
   Proposal ID      :    1662
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>The current project examines the effects of sleep profiles on ADRD risk and cardiovascular and lifestyle pathways.    AIM 1: Unique effects of sleep profiles on cognitive decline and ADRD. We will test whether individuals with suboptimal sleep profiles (e.g., multiple patterns or composite number of sleep problems across regularity, satisfaction, alertness, timing, duration, sleep apnea and other disorders) exhibit steeper cognitive decline [H1] and higher risk of ADRD [H2], than those with optimal sleep profiles but otherwise equal on background characteristics. Effect magnitude between sleep profiles vs. single sleep measures will be compared.  AIM 2: Cardiovascular mechanisms linking sleep profiles to cognitive decline and ADRD. The role of CVD risk factors in the link between sleep (considering multiple sleep dimensions) and cognitive risks is understudied. We will test whether diagnosed CVD and individual and composite risk biomarkers of CVD mediate the effects of sleep profiles on cognitive decline [H3] and incident ADRD [H4].    AIM 3: Lifestyle mechanisms (work/retirement) linking sleep profiles to cognitive decline and ADRD. The role of work and retirement in late life health is complex and may differ by occupational and retirement characteristics. MIDUS and MESA provide sizable groups of pre-retirement workers, retirees without paid work, and post-retirement workers and data on pre- and post-retirement experiences. We will explore how retirement status, retirement timing, occupational characteristics before retirement, and having a new job after retirement play roles in the longitudinal effects of sleep profiles on cognitive decline and ADRD risk.    This project will contribute new knowledge on (1) clinical meaning of sleep profiles in the risks for CVD and ADRD, (2) the combined contribution of sleep and CVD to cognitive decline and ADRD risk, and (3) the role of work and retirement in sleep, cardiovascular, and cognitive health. Findings will provide a </textarea>